TABLE 1.
Comparison of levofloxacin, alatrofloxacin, and vancomycin in the prophylactic treatment of tissue cage infection caused by S. aureus MRGR3
| Antibiotic (dose [mg/kg]) and no. of S. aureus CFU inoculated | No. of culture-negative samplesa/no. of samples analyzed (%) after:
|
||
|---|---|---|---|
| 48 h, fluid | 7 days
|
||
| Fluid | Coverslip | ||
| None (control), 103 | 0/12 (0) | 0/12 (0) | 0/12 (0) |
| Levofloxacin (50) | |||
| 103 | 12/12 (100) | 8/12 (67) | 8/12 (67) |
| 104 | 12/12 (100) | 8/12 (67) | 8/12 (67) |
| 105 | 11/12 (92) | 6/12 (50) | 6/12 (50) |
| Alatrofloxacin (50) | |||
| 103 | 12/12 (100) | 12/12 (100) | 9/12 (75) |
| 104 | 12/12 (100) | 8/12 (67) | 3/12 (25) |
| 105 | 9/12 (75) | 2/12 (17) | 1/12 (8) |
| Vancomycin (50) | |||
| 103 | 12/12 (100) | 12/12 (100) | 8/12 (67) |
| 104 | 9/12 (75) | 3/12 (25) | 0/12b (0) |
| 105 | 0/12c (25) | 0/12b (0) | 0/12b (0) |
a
The limits of detection were 102 CFU/ml and 1 CFU for tissue cage fluids and coverslips, respectively.
b
P < 0.05 for levofloxacin versus vancomycin.
c
P < 0.05 for levofloxacin or alatrofloxacin versus vancomycin