TABLE 1.

Gastrointestinal symptom scores (GSRS) over time.

GSRS scale	Pre	T1	T2	T3	Follow-up	P-value	FDR
Reflux	1.3 ± 0.4	1.3 ± 0.5	1.3 ± 0.6	1.6 ± 1.0	1.5 ± 0.6	0.268	0.537
Abdominal pain	1.5 ± 0.6	1.2 ± 0.3	1.3 ± 0.5	1.5 ± 0.8	1.4 ± 0.5	0.011*	0.064
Indigestion	1.8 ± 0.6	1.9 ± 0.7	1.9 ± 0.9	1.9 ± 0.9	1.9 ± 0.7	0.603	0.673
Diarrhea	1.5 ± 0.7	1.7 ± 0.7	1.7 ± 0.9	1.8 ± 1.1	1.7 ± 0.8	0.145	0.435
Constipation	1.4 ± 0.5	1.3 ± 0.4	1.3 ± 0.5	1.3 ± 0.5	1.4 ± 0.3	0.673	0.673
Total score	1.5 ± 0.4	1.5 ± 0.4	1.5 ± 0.6	1.6 ± 0.7	1.6 ± 0.4	0.504	0.673

Mean (±SD) total and subscale scores of the Gastrointestinal Symptom Rating Scale (GSRS) before isolation (Pre), during isolation (T1 = February, T2 = June, T3 = October), and 6 months post-isolation (Follow-up, T4). Scores range from 1 to 7, with higher values indicating greater symptom severity. Statistical significance was assessed using repeated measures analysis with false discovery rate (FDR) correction. Pairwise comparisons between time periods were Bonferroni-adjusted. Statistical significance was defined as p < 0.05, with significant effects indicated by an asterisk (*).