TABLE 2.
Recovery of C. immitis isolates 97-960 and 97-2036 from organs of mice treated with POSA and ITRA
Treatment (dose [mg/kg])a | % Sterilization
|
|||
---|---|---|---|---|
Isolate 97-960b
|
Isolate 97-2036c
|
|||
Spleen | Liver | Spleen | Liver | |
Controls | 0 | 0 | 0 | 0 |
POSA (0.01) | 0 | 0 | 0 | 0 |
POSA (0.1) | 0 | 0 | 0 | 0 |
POSA (0.5) | 0 | 0 | 0 | 0 |
POSA (1) | 0 | 0 | 0 | 0 |
POSA (5) | 60 | 50 | 50 | 30 |
POSA (10) | 80 | 70 | 80 | 80 |
ITRA (10) | 0 | 0 | 0 | 0 |
ITRA (30) | 0 | 0 | 0 | 0 |
Each group had 10 mice. The mice were monitored through day 50 postchallenge. The organs were homogenized, and whole organs were plated onto potato dextrose agar and incubated at 30°C for a week.
MIC, 0.25 μg/ml.
MIC, 1 μg/ml.