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. 2002 May;46(5):1352–1356. doi: 10.1128/AAC.46.5.1352-1356.2002

TABLE 2.

Recovery of C. immitis isolates 97-960 and 97-2036 from organs of mice treated with POSA and ITRA

Treatment (dose [mg/kg])a % Sterilization
Isolate 97-960b
Isolate 97-2036c
Spleen Liver Spleen Liver
Controls 0 0 0 0
POSA (0.01) 0 0 0 0
POSA (0.1) 0 0 0 0
POSA (0.5) 0 0 0 0
POSA (1) 0 0 0 0
POSA (5) 60 50 50 30
POSA (10) 80 70 80 80
ITRA (10) 0 0 0 0
ITRA (30) 0 0 0 0
a

Each group had 10 mice. The mice were monitored through day 50 postchallenge. The organs were homogenized, and whole organs were plated onto potato dextrose agar and incubated at 30°C for a week.

b

MIC, 0.25 μg/ml.

c

MIC, 1 μg/ml.