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. 2003 Dec 11;23(1):111–119. doi: 10.1038/sj.emboj.7600025

Figure 1.

Figure 1

SUR-7 is a cation diffusion facilitator protein. (A) Structure of sur-7 and lesion identified in sur-7(ku119). A G to A transition was identified in the 5′ splice site of the third intron. (B) Comparison between SUR-7 and a consensus for the CDF family of proteins. SUR-7 contains six transmembrane domains (shaded regions). Five of six domains align physically with those in other CDF proteins. Most CDF proteins have a histidine-rich loop with as many as 13 histidine residues between TMs IV and V. SUR-7 has a short H-rich region between TMs III and IV. (C) Alignment between SUR-7, CDF-1 and S. pombe Zhf-1. SUR-7 shares the greatest degree of identity with other CDF proteins from TM VI to its C-terminus. In this region, SUR-7 is 16% identical and 36% similar to CDF-1, and 17% identical and 32% similar to Zhf1. CDF-1 and Zhf1 are 24% identical and 44% similar over the same region. Black backgrounds represent identity and outlines represent similarity.