Figure 1.

Factors belonging to the TBP family encoded by different genomes are presented. The well-conserved core domains of these factors are displayed as saddle-like shapes. The nonconserved N- and C-terminal domains are shown as ‘noodles', and the lengths of these are proportional. Similar colours reflect high conservation, and different colours mean no or weak sequence homology. The target of these factors, a typical TATA box-containing (TATA@A@N) class II promoter with initiator element (arrow), or a promoter with TATA-less sequences (Recog. seq.), is diagrammed. Drosophila TRF2 (TLF) binds to promoters containing a DNA replication-related element (DRE). ‘?' indicates that binding of vertebrate TBP2 to TATA box-containing promoters has not yet been documented.