Table 1.

Critical role for the Tube–MyD88 interaction in Toll signaling

RNA injected	No. of embryos scored	Partial rescue (FK only) (%)	Strong rescue (FK and VD) (%)
MyD88 alleles
Wild-type	44	66	11
E80K	46	30	70
E89K	48	25	73
E107K/E108K	36	53	39
D113Ka	29	(3)b	0
E119K	64	67	14
D128K/E129K	34	6	0
D136K	39	72	8
E156K	42	24	62
D163Ka	36	0	0
D166Ka	24	0	0
D169K/D170Ka	28	0	0
E173K	31	58	26
D178K	24	0	0
E187K	21	5	90
E195K	35	11	54
D203K	55	33	51
E206K	33	6	0
Tube alleles
Wild-type	56	27	66
R34Ea	46	4	0
R35E	90	3	84
K87Ea	76	8	83
K87Da	44	20	0
R126Ea	27	0	0
For each construct, the columns indicate the number of injected embryos for which cuticle pattern elements could be scored, the percentage of embryos scored that differentiated filzkörper (FK), a dorsal–lateral patterning element, and the percentage of embryos scored that differentiated both ventral denticle (VD) bands and FK.
aMutations that block the interaction of Tube and MyD88 in the coimmunoprecipitation assay.
bFor the D113K mutation, 31% (9/29) of injected embryos have fine lateral denticle bands extending around the embryonic circumference, but no FK.