FIG. 1.

Amino acid sequence comparison of the Rif region of the rpoB gene of E. coli, Staphylococcus aureus, S. pneumoniae, and S. pyogenes. Clusters I, II, and III are indicated by a double line above the alignment. Dots indicate gaps introduced to optimize the alignment. Residues where substitutions are known to be involved in rifampin resistance are in bold. Mutations leading to rifampin resistance in S. pyogenes BM4478 and in Staphylococcus aureus BM4479 are indicated by double and single upward-pointing arrows, respectively.