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. 2025 Nov 20;17(11):e97307. doi: 10.7759/cureus.97307

Table 5. Five numerical indices to interpret the patient’s mixing test.

Each index was calculated as follows: ICA = ((c-d)/a) × 100, mixing test normalized ratio = c/d, 1:1 percent correction ((a-c)/(a-d)) × 100, 4:1 percent correction = ((a-b)/(a-d)) × 100, Mix–NPP = c-d, in which the APTT values (seconds) of a) neat test plasma, b) mixture of four parts test plasma to one part NPP, c) mixture of one part test plasma to one part NPP, d) NPP. The cutoff values used were determined as described in previous studies.

The gray column indicates the matched results with clinical diagnosis. Boldface is used to mark concordant results.

APTT, activated partial thromboplastin time; ICA, index of circulation anticoagulant; Mix, 1:1 mixture; NPP, normal pooled plasma

  Initial evaluation After FFP therapy Cutoff value for factor deficiency
Early Late Early Late
ICA (Rosner Index) 9.38 14.2 8.60 37.6 <12.4%
Mixing test normalization ratio 1.59 2.21 1.59 3.22 <1.12
1:1 percent correction 88.9 83.8 89.9 54.8 ≥72%
4:1 percent correction 52.6 46.7 61.1 25.0 ≥50%
Mix-TTP 16.0 35.1 16.0 64.5 <8 seconds