TABLE 2.
ANP |
ANPppKi/dNTPKmh
|
% fince, i
|
CC50f
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
pol α | pol δ | pol ɛ*g | pol α | pol δ | pol ɛ*g | MT4j (μM) | CEMk (μM) | F-PBMCk (μM) | hRPTECl (μM) | HELm (μg/ml) | |
PMEGa | 0.03 | ND | 0.004r | 6.4 | 40.2 | 5.9h | 11 | ≥0.8 | 0.23 | ND | 2.5 |
PMEDAPb | 0.3 | 0.1 | 1.3r | 2.6 | 20.5 | 4.2h | 18 | ND | ND | ND | 40 |
(S)-HPMPAc | 2.3 | 0.3 | 0.1r | 7.6 | 8.7 | 18.4r | 52; 26 | ND | ND | ND | 20 |
PMEAd | 1.2 | 0.6 | 0.9r | 0.7 | 4.4 | 2.0r | 67 | 64 | 24 | 500 | 100 |
(R)-PMPA | 10.2 | 10.2 | 15.6r | 0.11 | 0.03 | 0.08r | >300 | ≥500 | 165 | >2,000 | ND |
PMEG, 9-[(2-phosphonomethoxy)ethyl]guanine.
PMEDAP, 9-[(2-phosphomethoxy)ethyl]-2,6-diaminopurine.
(S)-HPMPA, (S)-9-[(3-hydroxy-2-phosphonomethoxy)propyl]adenine.
PMEA, 9-[(2-phosphonomethoxy)ethyl]adenine.
Percent finc = 100 × (ANPppVmax × dNTPKm)/(dNTPVmax × ANPppKm) (see reference 8).
CC50, 50% cytotoxic concentration; ND, not determined.
h, human DNA polymerases; r, rat DNA polymerases.
See reference 21.
See reference 1.
See reference 11.
See reference 2.