TABLE 3.

Inhibition of DNA pol α, δ, and ɛ∗ with PMPApp on template-primer poly(dT)-oligo(dA)_12-18^a

DNA pol	Kinetic constant valued		PMPAppKi/dATPKm
	dATPKm	PMPAppKi
pol α	10.0 ± 1.1	102.0 ± 9.5c	10.2
pol δ + PCNA	0.71 ± 0.08	7.2 ± 1.3b	10.2
pol ɛ∗	6.1 ± 2.3	95.3 ± 13.5b	15.6

^aReaction procedures were performed as described in the text. Kinetic constants are given as the means ± standard deviations from three independent experiments.

^bCompetitive inhibition.

^cUncompetitive inhibition.

^dMicromolar.