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WT and CDV-R cowpox (A and B) and monkeypox (C and D) virus yields from Vero 76 (monkey) and 3T3 (mouse) cells. Approximately 100 virus PFU/well was used to initiate each infection. Symbols: •, WT virus; ▪, WT (SF) virus; ▴, CDV-R virus; ⧫, CDV-R (SF) virus. The assay variability was no greater than ±3.2-fold (0.5 log10).
