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Treatment of intranasal infections with WT and CDV-R cowpox virus in SCID mice. Starting immediately after intranasal virus challenge, subcutaneous treatments (100 mg/kg) were given once daily every 3 days through day 30. Symbols: •, placebo-treated cowpox-WT virus-infected mice; ▪, cidofovir-treated cowpox-WT virus-infected mice; ○, placebo-treated cowpox-R (SF) virus-infected mice; □, cidofovir-treated cowpox-R (SF) virus-infected mice.
