Table 4. Diagnostic performance of HFC, CEA, CYFRA21-1, and LDH for malignant effusion associated with lung cancer.

Biomarkers	AUC	95% CI	Cutoff value	Sensitivity (%)	Specificity (%)
HFC# (/μL)	0.706	0.665–0.747	21	70.4	59.7
HFC% (/100WBC)	0.746	0.707–0.785	2.0	74.1	63.5
CEA (ng/mL)	0.882	0.854–0.910	3.1	79.5	89.4
CYFRA21-1 (ng/mL)	0.724	0.683–0.764	73.1	47.5	88.4
LDH (U/L)	0.523	0.475–0.570	166	84.5	29.7
HFC#+CEA	0.881	0.853–0.909		78.3	78.8
HFC%+CEA	0.884	0.858–0.910		74.6	79.3
Cyfra21-1+CEA	0.875	0.846–0.903		73.3	80.1