. 2002 May;46(5):1273–1280. doi: 10.1128/AAC.46.5.1273-1280.2002

TABLE 3.

Sequences of the three conserved amino acid motifs of PBPs 1a, 2x, and 2b that form the active penicillin-binding site cavities of the PBPs in S. pneumoniae R6 and the 18 study strains (sequences flanking these motifs are also shown where relevant)

Strain	Changes in amino acids of conserved PBP sites making up active penicillin-binding site of PBP:
	1a			2x			2b
	370-373^a	428-430	557-559	337-340	394-397	546-549	385-388	442-445	614-616
R6	STMK^b	SRN	KTG	STMK	HSSN	LKSG	SVVK	SSNT	KTG
1	`-^c`	`-`	`-`	`-`	`-`	`-`	`-`	`-`	`-`
2	`-`	`-`	`-`	`-`	`-`	`VKSG`	`-`	`-`	`-`
3	`-`	`-`	`-`	`-`	`-`	`-`	`-`	`SSNA`	`-`
4	`-`	`-`	`-`	`-`	`-`	`-`	`-`	`-`	`-`
5	`-`	`-`	`-`	`-`	`YSSN`	`-`	`-`	`SSNA`	`-`
6	`-`	`-`	`-`	`SPMK`	`-`	`-`	`-`	`SSNA`	`-`
7	`-`	`-`	`-`	`-`	`YSSN`	`-`	`-`	`SSNA`	`-`
8	`-`	`-`	`-`	`SPMK`	`-`	`-`	`-`	`SSNA`	`-`
9	`-`	`-`	`-`	`SAMK`	`-`	`-`	`-`	`SSNA`	`-`
10	`-`	`-`	`-`	`SAMK`	`-`	`-`	`-`	`SSNA`	`-`
11	`-`	`-`	`-`	`SAMK`	`-`	`VKSG`	`-`	`SSNA`	`-`
12	`-`	`-`	`-`	`SAMK`	`-`	`VKSG`	`-`	`SSNA`	`-`
13	`SAMK^d`	`-`	`-`	`SAMK`	`-`	`VKSG`	`-`	`SSNA`	`-`
14	`SAMK`	`-`	`-`	`SAMK`	`-`	`VKSG`	`-`	`SSNA`	`-`
15	`SAMK`	`-`	`-`	`SAMK`	`-`	`VKSG`	`-`	`SSNA`	`-`
16	`SAMK`	`-`	`-`	`SAMK`	`-`	`VKSG`	`-`	`SSNA`	`-`
17	`SSMK`	`-`	`-`	`SAFK`	`-`	`VKSG`	`-`	`SSNA`	`-`
18	`SSMK`	`-`	`-`	`SAFK`	`-`	`VKSG`	`-`	`SSNA`	`-`

Amino acid position numbers of amino acids shown in column below.

For S. pneumoniae R6, conserved amino acid motifs are shown in boldface and flanking amino acids (where applicable) are shown in regular typeface.

-, no change in amino acid motifs of test strains from those of S. pneumoniae R6.

Changes in amino acid motifs of test strains from those of S. pneumoniae R6 are shown in boldface for study strains.