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In vitro activity of AmB formulations on L. donovani intramacrophagic amastigotes. After WT strain infection (shaded bars), 86% of the macrophages were infected, and nontreated infected macrophages contained 10.2 ± 3.1 amastigotes 4 days postinfection. After AmB-R strain infection (hatched bars), 52% of the macrophages were infected, and nontreated infected macrophages contained 7.4 ± 2.6 amastigotes 4 days postinfection. IC50, 50% inhibitory concentration.
