TABLE 1.
Formulation | Concn (g/liter) of:
|
Size (nm) | AmB (% in water) | Size in PBS (nm) | AmB (% in PBS) | ||
---|---|---|---|---|---|---|---|
PSP | DPPG | AmB | |||||
ABV1 | 10 | 2 | 0 | 91 | 0 | 97 | 0 |
ABV2 | 10 | 5 | 0 | 97 | 0 | 111 | 0 |
ABV1/AmB | 10 | 2 | 2 | 96 | 97 | 118 | 92 |
ABV2/AmB | 10 | 5 | 2 | 107 | 95 | 121 | 90 |
The percentage of incorporated AmB was determined after sample filtration on 0.2-μm-pore-size filters. Under these conditions, nonformulated AmB did not pass through the filters (less than 1%).