Table 2.
Demographic and Baseline Characteristics
| Characteristic | Gabapentin (n = 79) | Vitamin B12 (n = 78) | Vitamin B1-6-12 (n = 80) | P |
|---|---|---|---|---|
| Sex Male Female |
11 (13.9) 68 (86.1) |
20 (25.6) 58 (74.4) |
12 (15.0) 68 (85.0) |
0.122 |
| Age, years | 64.1 ± 10.5 | 65.4 ± 9.5 | 63.4 ± 10.1 | 0.439 |
| BMI, kg/m2 | 24.8 ± 4.6 | 24.9 ± 4.5 | 26.4 ± 5.4 | 0.069 |
| BMI range, kg/m2 <18.5 18.5–22.9 23.0–24.9 25.0–29.9 ≥30.0 |
5 (6.3) 23 (29.1) 16 (20.3) 25 (31.6) 10 (12.7) |
6 (7.7) 18 (23.1) 16 (20.5) 29 (37.2) 9 (11.5) |
2 (2.5) 23 (28.7) 9 (11.3) 27 (33.7) 19 (23.7) |
0.257 |
| Comorbidities Hypertension Dyslipidemia Chronic kidney disease Cardiovascular disease Peripheral arterial disease Depressive symptoms Other |
75 (94.9) 69 (87.3) 67 (84.8) 9 (11.4) 0 (0.0) 0 (0.0) 1 (1.3) 4 (5.1) |
74 (96.1) 64 (82.1) 61 (78.2) 16 (20.5) 1 (1.3) 0 (0.0) 1 (1.3) 5 (6.4) |
78 (97.5) 69 (86.3) 71 (88.7) 10 (12.5) 1 (1.3) 0 (0.0) 1 (1.3) 5 (6.3) |
0.709 0.646 0.197 0.238 0.774 NA 1.000 0.944 |
| Chronic smoking | 4 (5.1) | 2 (2.6) | 4 (5.0) | 0.778 |
| Chronic alcohol drinking | 3 (3.8) | 3 (3.9) | 1 (1.3) | 0.573 |
| A1C, % | 7.5 ± 1.8 | 7.4 ± 1.6 | 7.6 ± 1.9 | 0.654 |
| A1C range, % <7.0 7.0–10.9 ≥11.0 |
38 (48.1) 37 (46.8) 4 (5.1) |
39 (50.0) 36 (46.1) 3 (3.6) |
38 (47.5) 37 (46.3) 5 (6.3) |
0.985 |
| Complications Diabetic retinopathy Diabetic ulcer |
2 (2.5) 2 (2.5) 0 (0.0) |
4 (5.1) 4 (5.1) 0 (0.0) |
4 (5.0) 4 (5.0) 0 (0.0) |
0.722 0.722 NA |
| Metformin dose, mg/day 0 500 1,000 1,500 2,000 2,500 3,000 |
8 (10.1) 5 (6.3) 31 (39.2) 8 (10.1) 25 (31.7) 1 (1.3) 1 (1.3) |
13 (16.7) 9 (11.5) 25 (32.1) 7 (9.0) 21 (26.9) 1 (1.3) 2 (2.7) |
17 (21.3) 8 (10.0) 25 (31.3) 6 (7.5) 20 (25.0) 4 (5.0) 0 (0.0) |
0.152 0.546 0.516 0.848 0.651 0.373 0.217 |
| Thai DN4 score at week 0 | 5.1 ± 1.4 | 5.0 ± 1.5 | 5.1 ± 1.5 | 0.805 |
Data are n (%) or mean ± SD. NA, not applicable.