TABLE 2.

PAFEs induced by exposure of Aspergillus species to amphotericin B

Strain	PAFE (h) obtained with indicated criterion, exposure time, and drug concna
	OD0				OD20				OD50
	4 h		2 h		4 h		2 h		4 h		2 h
	4×	1×	4×	1×	4×	1×	4×	1×	4×	1×	4×	1×
A. fumigatus
AZN VO2-31	9.3b	3.6b	1.8b	0.8	10.5b	5.6b	2.5	0.9	4.2b	2.8b	2.5	0.9
AZN VO2-32	9.7b	3.3b	6.0b	2.2b	8.9b	1.5	5.4b	2.5b	5.3b	3.7b	1.9	1.8
AZN VO2-33	10.8b	5.2b	4.3b	2.7b	7.1b	3.7b	6.5b	1.7b	6.5b	1.6	4.4b	0.1
A. terreus
AZN 5914	1.2	0.5	0.7	0.5	1.2	0.7	0.9	0.4	0.4	0.3	0.7	0.5
AZN 515	2.1b	0.4	0.2	0.1	4.2b	2.3b	0.8	0.6	4.3b	2.1b	0.4	0.6
AZN 2868	4.3b	2.1b	1.1b	0.4b	1.2b	0.8b	0.7b	0.2	1.4b	1.5b	0.6	0.7
A. ustus
AZN 677	4.2b	2.3b	1.3b	0.2b	2.9	1.9	1.5	0.3	3.2	2.3	3.3	0.3
AZN 678	5.8b	1.8b	1.2b	0.5b	3.1	2.1	1.2	0.1	4.8b	2.8b	0.1	0.3
AZN 943	1.8	1.2	0.5	0.5	5.2	2.1	1.8	0.8	2.9	1.5	2.9	1.3
A. nidulans
AZN 8950	0.3	−0.2	0.2	0.5	0.5	0.1	0.8	0.8	0.1	0.1	2.9	1.2
AZN 8033	0.8b	0.1b	0.2b	2.2b	1.5	3.1	4.9	0.9	4.6b	1.8b	2.0	0.5
AZN 8958	0.8b	0.7b	4.7	0.1	2.4	1.7	0.9	0.7	2.1	4.7	0.8	0.6
A. flavus
AZN 4094	1.7	0.1	−2.5	−3.2	2.1	0.1	−2.4	2.6	0.1	0.2	0.7	1.6
AZN 2865	3.5	−0.7	0.2	0.8	2.9	0.9	−4.5	1.7b	1.2	0.1	0.1	3.3
AZN 284	3.5b	1.0	0.2	1.8	2.8	−0.8	−3.0	1.4b	0.1	0.1	0.1	0.1

^a4×, 4 times the MIC; 1×, MIC.

^bPAFE was significant.