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. 1980 Mar;132(3):179–185.

Hyperthermia in Cancer Therapy

Kenneth H Luk 1,2, R Michael Hulse 1,2, Theodore L Phillips 1,2
PMCID: PMC1272016  PMID: 7376656

Abstract

Many malignant cell lines exhibit a therapeutic response to supernormal temperatures. Selective destruction of tumor cells has been observed following moderate hyperthermia (42° to 43° C) in vivo, and tumor eradication by heat has been achieved without normal tissue morbidity. Thermal cell killing appears to be independent of oxygen tension, and the sensitivity of S-phase cells to thermal damage is complementary to that for cellular radiation response. Hyperthermia is therefore a promising adjunct to radiotherapy. At the Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, San Francisco, the differential thermal sensitivity of malignant cells is being studied to achieve improved tumor control in patients refractory to more conventional treatments. Preliminary results of a two-year clinical trial indicated increased local objective responses when hyperthermia and radiation were used in combination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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