Table 2.
Characteristics of polymorphisms, socio-demographic variables and number of disorders in the total sample and in the latent classes
| Total (N=789) | Latent Class 1 (Higher psychiatric comorbidity) (n=161) | Latent Class 2 (Lower psychiatric comorbidity) (n=628) | p | ||
|---|---|---|---|---|---|
| BDNF functional genotype | GG | 396 (50.2) | 80 (49.7) | 316 (50.3) | 0.631 |
| AA | 351 (44.5) | 70 (43.5) | 281 (44.7) | ||
| GA | 42 (5.3) | 11 (6.8) | 31 (4.9) | ||
| 5HTTLPR functional genotype | L’/L’ | 129 (16.3) | 17 (10.6) | 112 (17.8) | 0.022 |
| L’/S’ | 393 (49.8) | 94 (58.4) | 299 (47.6) | ||
| S’/S’ | 267 (33.8) | 50 (31.1) | 217 (34.6) | ||
| BDNF+5HTTLPR Interaction | GA-AA + L’/L’ | 69 (8.7) | 11 (6.8) | 58 (9.2) | 0.129 |
| GA-AA + L’/S’-S’/S’ | 324 (41.1) | 70 (43.5) | 254 (40.4) | ||
| GG + L’/L’ | 60 (7.6) | 6 (3.7) | 54 (8.6) | ||
| GG + L’/S’-S’/S’ | 336 (42.6) | 74 (46.0) | 262 (41.7) | ||
| Sex | Female | 614 (77.8) | 149 (92.5) | 465 (74.0) | <0.001 |
| Male | 175 (22.2) | 12 (7.5) | 163 (26.0) | ||
| Age | Mean (SD) | 47.6 (16.5) | 47.3 (14.5) | 47.7 (17.0) | 0.781 |
| Educational level | Basic education or less | 436 (55.3) | 85 (52.8) | 351 (55.9) | 0.499 |
| High school | 287 (36.4) | 59 (36.6) | 228 (36.3) | ||
| Higher education | 66 (8.4) | 17 (10.6) | 49 (7.8) | ||
| Number of different forms of abuse experienced in childhooda | 0 | 425 (53.9) | 56 (34.8) | 369 (58.8) | <0.001 |
| 1 | 157 (19.9) | 34 (21.1) | 123 (19.6) | ||
| 2 | 160 (20.3) | 50 (31.1) | 110 (17.5) | ||
| 3 | 47 (6.0) | 21 (13.0) | 26 (4.1) | ||
| Presence of a family history of depression | No | 611 (77.4) | 100 (62.1) | 511 (81.4) | <0.001 |
| Yes | 178 (22.6) | 61 (37.9) | 117 (18.6) | ||
| Number of mental health disorders | Median (IQR) | 1.0 (0.0 to 2.0) | 4.0 (3.0 to 5.0) | 1.0 (0.0 to 1.0) | <0.001 |
a
Physical, psychological and/or sexual abuse (scale (sum) from 0 to 3).