TABLE 1.
CFU counts in the spleens of mice infected with M. tuberculosis and treated daily with increasing doses of MXF
| Drug regimen (mg/kg of body wt) | Mean CFU count (log10) ± SD at the following day of therapya:
|
|||
|---|---|---|---|---|
| 0 | 1 | 3 | 28 | |
| Untreated control | 3.91 ± 0.55 | 3.76 ± 0.16 | 4.30 ± 0.32 | 5.57 ± 0.16 |
| INH (25) | 3.66 ± 0.10 | 3.46 ± 0.27 | 1.37 ± 0.96** | |
| MXF (50) | 3.92 ± 0.25 | 3.22 ± 0.71 | 4.5 ± 0.22 | |
| MXF (100) | 3.42 ± 0.22 | 2.94 ± 0.08* | 2.52 ± 0.19 | |
| MXF (200) | 3.67 ± 0.016 | 3.18 ± 0.30* | 2.05 ± 0.25 | |
| MXF (400) | 3.61 ± 0.07 | 2.94 ± 0.27* | 0.37 ± 0.83** | |
a
*, P < 0.05 compared with pretreatment value. **, P > 0.05.