TABLE 3.

Relationship between gatifloxacin MIC and AUC/MIC necessary to achieve a static effect and 1 log₁₀ and 2 log₁₀ killing

Organism	MIC (μg/ml)	24-h AUC/MIC ratio required for:
		Static effect	1 log10 kill	2 log10 killing
S. pneumoniae CDC 145	0.25	37.0	45.8	56.1
S. pneumoniae CDC 146	0.25	54.8	66.7	81.4
S. pneumoniae CDC 673	0.25	53.6	64.4	78.4
S. pneumoniae CDC 1020	0.50	57.6	81.1	114
S. pneumoniae ATCC 10813	0.25	72.4	107.7	160.0
S. pneumoniae ATCC 49619	0.25	40.0	45.2	50.9
S. pneumoniae CDC 1396	0.50	18.4	24.9	33.8
S. pneumoniae MNO-418	8.0	23.1	33.4	45.3
S. pneumoniae T6-2668	2.0	51.3	80.5	128
Mean ± SD		52.0 ± 20.3	61.1 ± 26.4	83.1 ± 42.6
S. aureus ATCC 25923	0.12	27.2	47.8	76.5
S. aureus ATCC 33591	0.12	45.6	74.2	113
S. aureus ATCC 29213	0.12	29.7	54.5	90.9
S. aureus ATCC 6538p	0.06	43.2	131	507
Mean ± SD		36.4 ± 9.3	76.9 ± 37.8	197 ± 207
E. coli ATCC 25922	0.015	54.1	86.5	133
K. pneumoniae ATCC 43816 (thigh model, neutropenic mice)	0.06	69.7	129	235
K. pneumoniae ATCC 43816 (thigh model, nonneutropenic mice)	0.06	32.2	62.2	165a
K. pneumoniae ATCC 43816 (lung model, neutropenic mice)	0.06	55.9	96.1	153
K. pneumoniae ATCC 43816 (lung model, nonneutropenic mice)	0.06	43.2	63.2	91a
E. cloacae L2249	0.12	16.4	32.8	64.8
E. cloacae L4567	0.12	27.3	57.4	132
P. aeruginosa ATCC 27853	2.0	23.6	31.2	41.0
Mean ± SD		41.2 ± 21.5	72.2 ± 38.6	126 ± 68.8

^aDatum not included in calculation of the mean.