Skip to main content
. 2025 Oct 30;136(1):e191713. doi: 10.1172/JCI191713

Figure 2. Lnk deficiency moderately promotes survival of Fancd2–/– mice upon chronic replication stress, and combined loss of Lnk and Fancd2 does not exacerbate malignancies during aging.

Figure 2

(A) The top diagram depicts a schematic overview of chronic stress induced by repeated pIpC injection. Mice were injected i.p. with pIpC twice per week for 4 weeks, followed by 4 weeks of rest. This 8-week cycle was repeated 7 times. Event-free survival is graphed in Kaplan-Meier curves. n = 7–9 mice per group. P values are calculated by log-rank analysis. *P < 0.05. (B) Complete blood count analysis of peripheral blood from WT, Fancd2–/– (D2), Lnk–/– (Lnk), and Fancd2–/– Lnk–/– (DKO) mice, aged between 12 and 18 months. WBC, white blood cell. Each symbol represents an individual mouse. Horizontal lines indicate mean frequencies, and error bars indicate SEM. P values were calculated using 1-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (C) A cohort of mice was observed for aging analysis. n = 11–16 per group. Event-free survival is graphed in Kaplan-Meier curves. P values were calculated by log-rank analysis. *P < 0.05, **P < 0.01.