FIG. 3.

The effect of ciprofloxacin on killing by PMNs with an impaired respiratory burst. Experimental conditions were similar to those described for Fig. 1 (lower panel), except that phenylbutazone (0.2 mg/ml final concentration) was added to subaliquots of bacteria alone, bacteria plus PMNs, bacteria plus ciprofloxacin, and bacteria plus ciprofloxacin-loaded PMNs. The data are presented as the means ± SEM of CFU recovered after 30 min. The asterisk denotes a significant difference in killing between control and phenylbutazone-treated PMNs (P = 0.015; paired t test).