TABLE 1.

Potencies and conformity parameters for NNRTIs, NRTIs, and NFV against HIV-1 RT activity and HIV-1 (RF) replication^a

Compound group and compound	HIV-1 (RF) replication		HIV-1 RT activity
	IC50 (μM)b	r2	IC50 (μM)b	r2
NNRTIs
Efavirenz	0.0007 ± 0.0004	0.966	0.041 ± 0.012	0.981
DPC082	0.0004 ± 0.0001	0.966	0.054 ± 0.020	0.993
DPC083	0.0003 ± 0.0001	0.950	0.041 ± 0.0009	0.976
DPC961	0.0004 ± 0.0003	0.926	0.024 ± 0.004	0.973
DPC963	0.0004 ± 0.0002	0.967	0.019 ± 0.003	0.979
NVP	0.018 ± 0.003	0.938	2.34 ± 0.21	0.985
NRTIs
AZT	0.022 ± 0.014	0.973	0.0029 ± 0.0004	0.990
3TC	0.153 ± 0.023	0.987	1.45 ± 0.53	0.991
PI, NFV	0.005 ± 0.001	0.959	NDc	ND

^aAll values are derived from a minimum of 10 independent experiments for each compound in each assay.

^bValues are means ± standard deviations.

^cND, not determined.