TABLE 1.
Compartmental pharmacokinetic parameters in persistently neutropenic rabbits with experimental subacute disseminated candidiasisa
| Micafungin dosage (mg/kg) | Cmax (μg/ml) | Cmin (μg/ml) | AUC0-24 (μg · h/ml) | AUC0-∞/dose | VSS (liter/kg) | CL (liter/h/kg) | t112 (h) |
|---|---|---|---|---|---|---|---|
| 0.25 | 9.31 ± 1.11 | 0.02 ± 0.00 | 5.32 ± 0.25 | 9.16 ± 0.67 | 0.283 ± 0.04 | 0.043 ± 0.00 | 5.37 ± 0.77 |
| 0.5 | 16.27 ± 4.17 | 0.04 ± 0.01 | 9.75 ± 1.29 | 8.26 ± 1.12 | 0.298 ± 0.03 | 0.051 ± 0.00 | 4.91 ± 0.41 |
| 1.0 | 20.44 ± 4.92 | 0.05 ± 0.01 | 14.47 ± 2.03 | 5.90 ± 0.72 | 0.277 ± 0.03 | 0.052 ± 0.00 | 4.34 ± 0.44 |
| 2.0 | 25.21 ± 2.39 | 0.14 ± 0.01 | 36.33 ± 1.28 | 6.92 ± 0.30 | 0.326 ± 0.01 | 0.053 ± 0.00 | 4.56 ± 0.11 |
| P (ANOVA) | 0.0275 | <0.0001 | <0.0001 | 0.0413 | 0.8247 | 0.2915 | 0.5508 |
a
Values are means ± SEMs for six to eight rabbits each. VSS, apparent volume of distribution at steady state; CL, total clearance from plasma; t112, elimination half-life.