TABLE 2.
Compartmental pharmacokinetic parameters in persistently neutropenic rabbits with experimental invasive pulmonary aspergillosisa
| Micafungin dosage (mg/kg) | Cmax (μg/ml) | Cmin (μg/ml) | AUC0-24 (μg · h/ml) | AUC0-∞/dose | VSS (liter/kg) | CL (liter/h/kg) | t112 (h) |
|---|---|---|---|---|---|---|---|
| 0.5 | 13.36 ± 1.61 | 0.09 ± 0.00 | 11.47 ± 1.25 | 9.44 ± 1.07 | 0.407 ± 0.07 | 0.045 ± 0.00 | 6.77 ± 0.51 |
| 1.0 | 18.48 ± 1.40 | 0.16 ± 0.02 | 22.86 ± 2.86 | 9.15 ± 1.10 | 0.391 ± 0.05 | 0.049 ± 0.00 | 5.64 ± 0.43 |
| 2.0 | 22.49 ± 1.22 | 0.36 ± 0.07 | 45.57 ± 3.60 | 9.22 ± 0.74 | 0.419 ± 0.05 | 0.045 ± 0.00 | 6.78 ± 0.74 |
| P (ANOVA) | 0.0008 | 0.0020 | <0.0001 | 0.9789 | 0.9440 | 0.7695 | 0.2667 |
a
Values are means ± SEMs for 10 to 12 rabbits each. VSS, apparent volume of distribution at steady state; CL, total clearance from plasma; t1/2, elimination half-life.