TABLE 2.
Creatinine levels and leukocyte counts in rat plasma observed at sacrifice, i.e., 24 h after therapy initiation
| β-Lactama | No. of animals | Median (range) creatinine level in plasma (μmol/liter) | Median (range) leukocyte count in plasma (/mm3) |
|---|---|---|---|
| None | 15 | 253 (188-465) | 310 (210-750) |
| Imipenem | 15 | 263 (175-440) | 280 (160-480) |
| Cefepime | 16 | 229 (171-412) | 335 (150-880) |
| Ceftazidime | 16 | 336 (225-496) | 350 (170-740) |
| Piperacillin-tazobactam | 16 | 263 (181-538) | 260 (120-350) |
| Aztreonam | |||
| LD | 16 | 233 (157-333) | 280 (80-540) |
| HD | 16 | 265 (179-421) | 260 (70-750) |
a
LD, low dose; HD, high dose.