TABLE 3.

Titers of VIM-2 producing P. aeruginosa in rat lungs according to treatment groups and statistical differences between groups

Treatmentb	No. of animals	Median (range) lung bacterial titer (log10 CFU/g)	Statistical differencea (P value) compared to:
			Control group	Low-dose aztreonam group
Control	15	5.0 (3.0-9.0)		0.25
Imipenem	16	3.3 (2.3-4.1)	0.004	0.001
Cefepime	16	3.3 (2.6-5.7)	0.01	0.009
Ceftazidime	16	3.3 (2.3-7.2)	0.04	0.13
Piperacillin-tazobactam	16	3.3 (2.3-6.0)	0.03	0.26
Aztreonam
LD	16	4.0 (3.3-6.3)	0.25
HD	15	2.8 (2.3-6.4)	0.002	0.003

^aValues showing a significant difference are in bold.

^bLD, low dose; HD, high dose.