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[Preprint]. 2025 Dec 16:2025.12.16.694696. [Version 1] doi: 10.64898/2025.12.16.694696

Figure 2. Interactions between DPAGT1/MraY and APPB.

Figure 2.

(a,b) Cryo-EM Coulomb potential maps of APPB in DPAGT1 (a) and MraY (b), with APPB modeled as sticks. APPB conformations correspond with cis (neon green) and trans (forest green) central amides. Conformers are referred to as cisDPAGT1, transDPAGT1, cisMraY, or transMraY. Detailed local interactions of cisDPAGT1 (c), transDPAGT1 (d), cisMraY (e), transMraY (f). The protein is shown in ribbon form, APPB-contacting residues are shown as sticks, and waters are represented by red spheres. Dashed lines indicate potential H-bonding interactions based on non-hydrogen atom distances <3.5 Å. Schematic representations of APPB interactions can be found in Figure S11.