TABLE 2.
Steady-state pharmacokinetic parameter estimates for FTCa
| Cohort (FTC q.d. dose [mg]) | Cmax (μg/ml) | Tmax (h) | AUC0-24 (μg · h/ml) | t1/2 (h) | CL/F (ml/min) |
|---|---|---|---|---|---|
| 25 (n = 9) | 0.43 (0.17) | 1.14 (0.58) | 1.76 (0.45) | 9.32 (2.66) | 250 (57) |
| 50 (n = 8) | 0.65 (0.17) | 1.20 (0.39) | 2.81 (0.43) | 9.05 (1.66) | 303 (48) |
| 100 (n = 11) | 1.70 (0.50) | 1.48 (0.60) | 6.27 (1.33) | 6.81 (1.35) | 279 (67) |
| 200 (n = 9) | 3.00 (0.78) | 1.50 (1.03) | 12.79 (3.46) | 6.68 (1.36) | 277 (70) |
| 300 (n = 10) | 4.25 (1.14) | 1.29 (0.33) | 17.39 (3.49) | 5.86 (1.47) | 297 (56) |
a
The values are means (standard deviations). Tmax, time to Cmax; AUC0-24, AUC from 0 to 24 h; t1/2, half-life; CL/F, apparent total body clearance.