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ED50 and MIC ratios of cytotoxic to trypanocidal activities of proteasome inhibitorsa
| Compound | ED50 (HL-60)/ED50 (T. brucei) | MIC (HL-60)/MIC (T. brucei) |
|---|---|---|
| AC-Leu-Leu-Nle-CHO | 102 | >1 |
| AC-Leu-Leu-Met-CHO | 13 | >1 |
| Z-Ile-Glu(OtBu)-Ala-Leu-CHO | 419 | 2,500 |
| Z-Leu-Leu-Leu-CHO | 13 | >25 |
| Z-Leu-Leu-Phe-CHO | 0.8 | 14 |
| Z-Leu-Leu-Tyr-COCHO | 4 | >1 |
| Z-Leu-Leu-Leu-B(OH)2 | 3 | 100 |
ED50 and MIC ratios were calculated from ED50s and MICs shown in Table 1.
