TABLE 1.
Activity of BAY 57-1293 versus those of current drugs in the murine lethal challenge model
| Compound | ED50 (mg/kg)
|
|
|---|---|---|
| HSV-1 | HSV-2 | |
| BAY 57-1293 | 0.5 | 0.5 |
| Ganciclovir | 2.5 | 1.0 |
| Valacyclovir | 17 | 15 |
| Famciclovir | 17 | 24 |
| Acyclovir | 22 | 16 |
| Brivudin | 37 | >60 |
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