FIG. 3.

Effect of treatment of infected rabbits on bacterial load (CFU in tissues) in brains, lungs, and spleens at necropsy. Control rabbits were infected and not treated (C). Another group of rabbits was infected and treated with antibiotics (isoniazid plus rifampin) (A). A third group of rabbits was infected and treated with the same antibiotics combined with thalidomide (A+T). The fourth group was infected and treated with the same antibiotics combined with IMiD3 (A+I). Treatment was initiated on days 16 and 17 as described in Materials and Methods and continued to day 28 postinfection. Results are for individual animals. The bar denotes the median for the animals tested. Statistically significant differences are denoted by the P values shown at the tops of the graphs.