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The apparent volumes of distribution of terbinafine in human tissues, with values scaled up from those in rat tissues
| Tissue | Apparent Vss (liter)a | % of total Vssb |
|---|---|---|
| Adipose | 399.2 | 52.3 |
| Skin | 316.1 | 41.4 |
| Small intestine | 5.1 | 0.7 |
| Stomach | 1.1 | 0.1 |
| Testis | 0.1 | 0.01 |
| Liver | 1.3 | 0.2 |
| Lung | 3.1 | 0.4 |
| Heart | 0.5 | 0.1 |
| Kidney | 0.9 | 0.1 |
| Brain | 1.7 | 0.2 |
| Spleen | 0.3 | 0.04 |
| Muscle | 28.8 | 3.8 |
| Arterial blood | 1.8 | 0.2 |
| Venous blood | 3.6 | 0.5 |
Calculations based on equation 2.
Total Vss, 763.5 liters.
