TABLE 2.
Antibiotic | Cmax (mg/liter) | Human dosage yielding a similar Cmax in serumb (reference) | Cmax/MICc |
---|---|---|---|
Ampicillin | 50 | 1 g i.v. (17) | 167 |
Meropenem | 50 | 1 g i.v. (9) | 694 |
Ciprofloxacin | 4.3 | 750 mg p.o. (Bayer Corp.d) | 3 |
Moxifloxacin | 4 | 400 mg p.o. (44) | 7 |
Azithromycin | 0.4 | 500 mg p.o. (16) | 0.9 |
Gentamicin | 18 | 5 mg/kg i.v.e (21) | 22 |
The Cmax were meant to mimic the maximal concentrations obtainable in serum in vivo after the administration of commonly accepted dosages to humans.
i.v., intravenously; p.o., orally.
Based on the MICs observed in macrophage culture medium (see Table 1).
Bayer Corporation (U.S. ciprofloxacin package insert, 2000).
Once-daily dosing.