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. 2002 Jul;46(7):2095–2103. doi: 10.1128/AAC.46.7.2095-2103.2002

TABLE 2.

Cmax of the antibiotics useda and corresponding Cmax/MIC ratios

Antibiotic Cmax (mg/liter) Human dosage yielding a similar Cmax in serumb (reference) Cmax/MICc
Ampicillin 50 1 g i.v. (17) 167
Meropenem 50 1 g i.v. (9) 694
Ciprofloxacin 4.3 750 mg p.o. (Bayer Corp.d) 3
Moxifloxacin 4 400 mg p.o. (44) 7
Azithromycin 0.4 500 mg p.o. (16) 0.9
Gentamicin 18 5 mg/kg i.v.e (21) 22
a

The Cmax were meant to mimic the maximal concentrations obtainable in serum in vivo after the administration of commonly accepted dosages to humans.

b

i.v., intravenously; p.o., orally.

c

Based on the MICs observed in macrophage culture medium (see Table 1).

d

Bayer Corporation (U.S. ciprofloxacin package insert, 2000).

e

Once-daily dosing.