TABLE 3.
Pharmacokinetic serum parameters of quinupristin, dalfopristin, and Q-D in three healthy rabbits after a single intramuscular injection of Q-D (30 mg/kg)a
| Drug | Cmax (mg · liter−1) | AUC (h · mg · liter−1) | β half-life (h) |
|---|---|---|---|
| Quinupristin | 1.5 ± 0.4 | 4.0 ± 2.3 | 1.5 ± 1.5 |
| Dalfopristin | 6.9 ± 0.5 | 6.8 ± 3.3 | 0.7 ± 0.3 |
| Q-D | 5.4 ± 1.8 | 6.0 ± 2.6 | 0.6 ± 0.3 |
a
Mean values ± SD of peak concentrations (Cmax), areas under the curve (AUC), and β half-lives are shown. Peak concentrations were observed 15 min after injection for dalfopristin and 30 min after injection for quinupristin and Q-D.