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Activity of drugs in 1-day regimensc
| Regimen | Log10 CFU/g of vegetation (no. of animals) with S. aureus strain:
|
|
|---|---|---|
| NA8 | BCB8 | |
| Control (untreated) | 8.5 ± 0.8 (9) | 8.7 ± 0.9 (13) |
| Gentamicin | 4.2 ± 1.3 (6)a | 7.2 ± 2.0 (5) |
| Q-D | 4.0 ± 1.1 (8)a | 5.3 ± 1.7 (7)b |
| Gentamicin + Q-D | 3.8 ± 0.4 (4)a | 5.5 ± 2.8 (8)b |
P < 0.001 versus controls.
P < 0.01 versus controls.
Values are mean bacterial titers in vegetations ± SD. Statistical significance was determined by Scheffe's test after ANOVA.
