2D	Two-dimensional
3D	three-dimensional
AI	artificial intelligence
AUC	area under the curve
CCLE	Cancer Cell Line Encyclopedia
CDx	companion diagnostic
CMap	Connectivity Map
DepMap	Dependency Map
dMMR	mismatch-repair–deficient
EHRs	electronic health records
GDSC	Genomics of Drug Sensitivity in Cancer
GANs	generative adversarial networks
HCQ	Hydroxychloroquine
MBZ	Mebendazole
MSI-H	microsatellite-instability-high
NAMs	New Approach Methodologies
NSCLC	non–small-cell lung cancer
PD	Pharmacodynamics
PDO	patient-derived organoid
PDX	patient-derived xenograft
PK	Pharmacokinetics
ReDO	Repurposing Drugs in Oncology
RNAi	RNA interference
sgRNAs	small guide RNAs
shRNAs	short hairpin RNAs