TABLE 2.

In vitro CIs for LPV and other PIs

PI	Ratio	CI (95% confidence interval) for % inhibition ofa:
		50	75	90	95
SQV	0.5	0.86 (0.76, 0.97)	0.79 (0.64, 0.94)	0.72 (0.53, 0.92)	0.68 (0.46, 0.91)
	1	0.88 (0.79, 0.98)	0.82 (0.69, 0.95)	0.76 (0.60, 0.93)	0.72 (0.53, 0.91)
	2	0.81 (0.73, 0.90)	0.77 (0.64, 0.90)	0.73 (0.57, 0.89)	0.70 (0.52, 0.89)
	4	0.85 (0.77, 0.94)	0.77 (0.66, 0.88)	0.70 (0.56, 0.84)	0.66 (0.49, 0.82)
	8	0.87 (0.79, 0.94)	0.79 (0.69, 0.90)	0.73 (0.59, 0.87)	0.69 (0.53, 0.84)
IDV	0.1	0.94 (0.85, 1.03)	0.83 (0.71, 0.94)	0.73 (0.58, 0.88)	0.67 (0.50, 0.83)
	0.2	0.99 (0.90, 1.08)	0.94 (0.81, 1.07)	0.89 (0.72, 1.07)	0.86 (0.66, 1.07)
	0.4	1.04 (0.94, 1.14)	1.03 (0.88, 1.17)	1.02 (0.83, 1.21)	1.01 (0.77, 1.25)
	0.8	1.01 (0.92, 1.10)	0.97 (0.84, 1.10)	0.93 (0.75, 1.10)	0.90 (0.70, 1.10)
	1.6	1.04 (0.93, 1.14)	0.98 (0.83, 1.13)	0.93 (0.72, 1.14)	0.90 (0.64, 1.15)
APV	0.1	0.96 (0.86, 1.06)	0.90 (0.76, 1.04)	0.84 (0.66, 1.03)	0.81 (0.59, 1.02)
	0.2	0.98 (0.88, 1.08)	0.94 (0.81, 1.08)	0.91 (0.72, 1.10)	0.88 (0.67, 1.10)
	0.4	1.00 (0.91, 1.09)	1.04 (0.90, 1.18)	1.08 (0.88, 1.28)	1.10 (0.84, 1.36)
	0.8	1.01 (0.91, 1.12)	0.94 (0.80, 1.08)	0.87 (0.69, 1.05)	0.82 (0.62, 1.03)
	1.6	0.96 (0.86, 1.06)	0.86 (0.72, 0.99)	0.77 (0.60, 0.93)	0.71 (0.52, 0.90)
NFV	0.25	1.09 (0.97, 1.22)	1.06 (0.88, 1.25)	1.03 (0.77, 1.29)	1.01 (0.71, 1.32)
	0.5	0.95 (0.86, 1.04)	0.92 (0.79, 1.05)	0.90 (0.72, 1.07)	0.87 (0.67, 1.08)
	1	1.11 (1.01, 1.21)	1.20 (1.04, 1.36)	1.30 (1.05, 1.56)	1.38 (1.05, 1.71)
	2	0.99 (0.90, 1.09)	0.98 (0.84, 1.11)	0.96 (0.77, 1.15)	0.95 (0.72, 1.18)
	4	0.98 (0.88, 1.08)	0.94 (0.80, 1.08)	0.90 (0.71, 1.09)	0.87 (0.65, 1.10)
TPV	0.032	0.85 (0.79, 0.92)	0.77 (0.69, 0.86)	0.70 (0.59, 0.81)	0.66 (0.54, 0.78)
	0.063	0.92 (0.84, 0.99)	0.86 (0.77, 0.96)	0.82 (0.69, 0.95)	0.79 (0.63, 0.94)
	0.125	0.99 (0.91, 1.07)	0.99 (0.88, 1.10)	0.99 (0.84, 1.15)	1.00 (0.81, 1.19)
	0.25	0.99 (0.90, 1.07)	0.95 (0.84, 1.07)	0.93 (0.77, 1.08)	0.91 (0.72, 1.09)
	0.50	0.93 (0.85, 1.01)	0.87 (0.76, 0.99)	0.82 (0.67, 0.97)	0.78 (0.61, 0.96)
BMS	2	1.06 (0.97, 1.15)	1.03 (0.90, 1.15)	0.99 (0.82, 1.16)	0.97 (0.76, 1.17)
	4	0.93 (0.86, 1.01)	0.86 (0.76, 0.96)	0.79 (0.66, 0.92)	0.75 (0.60, 0.90)
	8	1.05 (0.96, 1.14)	1.04 (0.91, 1.16)	1.02 (0.85, 1.20)	1.01 (0.81, 1.22)
	16	0.97 (0.88, 1.06)	0.89 (0.77, 1.01)	0.82 (0.66, 0.97)	0.77 (0.60, 0.94)
	32	0.91 (0.83, 1.00)	0.82 (0.70, 0.93)	0.73 (0.59, 0.87)	0.68 (0.52, 0.84)

^aBold text indicates those combinations tested for which the 95% confidence intervals did not bracket a combination index of 1.