TABLE 1.
Survival of mice treated with posaconazole, itraconazole, or amphotericin B
| Isolate | Inoculum (CFU/mouse) | Drug | Dose (mg/kg) | Survival (median no. of days) | Survival range (no. of days) | P valuea |
|---|---|---|---|---|---|---|
| 98-1763 | 3.2 × 105 | None | NA | 4 | 3->15 | NA |
| Posaconazole | 5 | 5 | 3->15 | 0.2535 | ||
| Posaconazole | 15 | 5 | 3->15 | 0.0458* | ||
| Posaconazole | 30 | 10 | 5->15 | 0.0019* | ||
| Itraconazole | 30 | 4 | 3-6 | 0.0810 | ||
| 00-1194 | 2.7 × 105 | None | NAb | 5 | 4-10 | NA |
| Posaconazole | 5 | 5 | 4-6 | 0.3460 | ||
| Posaconazole | 15 | 5 | 4->15 | 0.0015* | ||
| Posaconazole | 30 | 7 | 5->15 | 0.0001* | ||
| Itraconazole | 30 | 4 | 3-6 | 0.2320 | ||
| 95-2650 | 5.3 × 104 | None | NA | 5 | 4-6 | NA |
| Posaconazole | 30 | 9 | 5->15 | 0.0001* | ||
| 00-1194 | 5.8 × 105 | None | NA | 4 | 3-6 | NA |
| Posaconazole | 15 | 6 | 4->15 | 0.0002* | ||
| Posaconazole | 30 | 8 | 4->15 | 0.0001* | ||
| Itraconazole | 30 | 4 | 3-5 | 0.5086 | ||
| Amphotericin B | 1 | >15 | 2->15 | 0.0004* |
a
Values marked with an asterisk show significance in prolonging survival over that of the controls. A P value of ≤0.05 is needed for significance.
b
NA, not applicable.