TABLE 2.
Tissue burdens in the kidneys of mice infected with isolate 00-1194
| Inoculum (CFU/mouse) | Drug | Dose (mg/kg) | Median no. of CFU/g (104) | Range of CFU/g (104) | P valuea |
|---|---|---|---|---|---|
| 2.8 × 105 | None | NAb | 6.4 | 3.7-22 | NA |
| Posaconazole | 15 | 3 | 0.5-7 | 0.0148* | |
| Posaconazole | 30 | 4 | 0.2-2.8 | 0.0002* | |
| Itraconazole | 30 | 6.8 | 2.6-2 | 1.000 | |
| 2.6 × 104 | None | NA | 16 | 0.05-64 | |
| Posaconazole | 15 | 3.7 | 0.0001-28 | 0.0281* | |
| Posaconazole | 30 | 0.02 | 0.0001-2.6 | 0.0011* | |
| Itraconazole | 30 | 9 | 0.5-20 | 0.2345 | |
| Amphotericin B | 1 | 0.0001 | 0.0001-0.0053 | 0.0002* |
a
Values marked with an asterisk show significance in reducing kidney counts to levels lower than those found in the controls. A P value of ≤0.05 is needed for significance.
b
NA, not applicable.