TABLE 3.
Mutagenic action of sublethal concentrations of MTZ, NTZ, and furazolidone on Mtzs and Mtzr H. pylori
| Drug concn (μg/ml) | Mutation frequency (no. Rifr/108)
|
|||||
|---|---|---|---|---|---|---|
| Metronidazole
|
Nitazoxanide
|
Furazolidone
|
||||
| WT (EOP)a | rdxA (EOP) | WT (EOP) | rdxA (EOP) | WT (EOP) | rdxA (EOP) | |
| 0 | 12 (1) | 8 (1) | 2.27 (1) | 6.10 (1) | 1.0 (1) | 4.35 (1) |
| 0.25 | NTb | NT | 1.27 (1) | NT | 2.64 (0.1) | 16.43 (1) |
| 0.5 | NT | NT | 1.50 (1) | 2.94 (1) | 6.90 (0.1) | 64.91 (0.1) |
| 1.0 | 14 (1) | 5 (1) | 1.41 (0.5) | 4.46 (1) | 0 (10−3) | 0 |
| 2.0 | 69 (10−2) | 10 (1) | 0.97 (0.1) | 2.47 (1) | NT | NT |
| 3.0 | 144 (10−2) | 5 (1) | NT | NT | NT | NT |
| 5.0 | 0 (0) | 12 (1) | 0 (10−5) | 5.26 (0.5) | NT | NT |
| 10.0 | NT | NT | NT | 0 (10−8) | NT | NT |
| 25.0 | NT | 213 (10−2) | NT | NT | NT | NT |
a
Strains used were 26695 and the rdxA mutant. 0, insufficient survivors from which to calculate a mutation frequency. The data represent the means of three determinations each from two independent experiments. WT, wild type.
b
NT, not tested.