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Inhibition of InhA activity by an isolated pool of INH-NAD(H) adducts and by collected single INH-NAD(H) and INH-DNAD(H) adducts
| Run no. | Adduct | HPLC-collected peak | % Activity of InhA remaining
|
|
|---|---|---|---|---|
| Adduct (1 μM) | Adduct (5 μM) | |||
| 1 | INH-NAD(H) | Pool | 65 ± 9 | 18 ± 1 |
| 2 | INH-NAD(H) | 6 | 67 ± 1 | 29 ± 4 |
| 3 | INH-NAD(H) | 7 | 102 ± 7 | 69 ± 3 |
| 4 | INH-DNAD(H) | 11 | 106 ± 2 | 96 ± 3 |
| 5 | INH-DNAD(H) | 12 | 91 ± 3 | 74 ± 3 |
