| Challenge (From Literature) | Relevant Text/Excerpt in WHO Pandemic Agreement | Article Number(s) | Degree of Coverage | Notes/Gap Observations |
| Weak global coordination and fragmented governance structures | “Each Party shall cooperate and coordinate with international, regional and subregional organizations to strengthen pandemic prevention, preparedness, and response.” | Art. 3 (Purpose and Principles), Art. 4 (Scope and Relationship with Other Instruments) | Partial | Coordination language remains general; no clear mechanism for operational integration across governance levels. |
| Limited transparency and information-sharing | “Parties shall promptly share information on public health events and ensure timely reporting to WHO.” | Art. 11 (Information Sharing and Notification) | Full | Introduces binding reporting obligations and defines timeliness but lacks verification and enforcement mechanisms. |
| Insufficient sustainable financing mechanisms | “A Coordinating Financial Mechanism shall be established to mobilize predictable and sustainable resources.” | Art. 13 (Sustainable Financing), Art. 18 (Cooperation and Support) | Partial | Financing principles established, but implementation and monitoring arrangements remain vague. |
| Lack of enforceable legal accountability | “A Conference of the Parties (COP) shall oversee implementation, review progress, and promote compliance.” | Art. 17 (Implementation and Monitoring) and Art. 31 (COP) | Partial | Oversight depends on voluntary reporting; no independent compliance body or sanctions. |
| Weak integration of the One Health approach | “Parties shall adopt a One Health approach that integrates human, animal, and environmental health.” | Art. 5 (Objectives), Art. 12 (One Health and Prevention) | Partial | Framework acknowledges One Health but lacks operational standards or intersectoral funding mechanisms. |
| Limited empowerment of subnational and regional actors | — | — | None | The treaty does not explicitly include regional or local authorities, limiting subsidiarity and contextual responsiveness. |
| Unclear provisions for equitable data governance and benefit sharing | “A Pathogen Access and Benefit-Sharing (PABS) System shall be established to ensure fair and equitable sharing of benefits.” | Art. 10 (PABS System) + PABS Annex (draft) | Pending | Annex not finalized; data governance and equity metrics remain undefined. |
| Weak enforcement and compliance measures | “The COP shall adopt procedures and mechanisms to promote compliance.” | Art. 31 (COP) | Partial | No independent monitoring or sanction mechanisms; compliance largely self-reported. |