TABLE 1.
Summary of drug interaction for the four combinations tested
| Genera (no. of strains) | % of isolates showing synergism, additivity, and antagonism for the combinationa:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMB and RIF
|
AMB and 5FC
|
TER and AMB
|
TER and VRZ
|
|||||||||
| Syn | Add | Ant | Syn | Add | Ant | Syn | Add | Ant | Syn | Add | Ant | |
| Rhizopus spp. (15) | 40 | 60 | 0 | 0 | 100 | 0 | 27 | 73 | 0 | 60 | 40 | 0 |
| Absidia spp. (10) | 100 | 0 | 0 | 0 | 100 | 0 | 10 | 90 | 0 | 0 | 100 | 0 |
| Other (10) | 80 | 20 | 0 | 0 | 100 | 0 | 20 | 80 | 0 | 67 | 33 | 0 |
| All isolates (35) | 69 | 31 | 0 | 0 | 100 | 0 | 20 | 80 | 0 | 44 | 56 | 0 |
a
AMB, amphotericin B; RIF, rifampin; 5FC, 5-fluorocytosine; TER, terbinafine; VRZ, voriconazole. Syn, synergism (FIC index ≤ 0.5); Add, additivity or indifference (FIC index > 0.5 and ≤ 4); Ant, antagonism (FIC index > 4).