| Ligand | UV-Vis Evolution | ΔGrs (Thermodynamic Stability) | Conclusion |
| Picolinic Acid (B3_D) | Fastest and most complete reaction. | Lowest affinity (least negative ΔGrs among pyridines). | The chelate effect provides a kinetic advantage, enabling a faster reaction, but the resulting complex is the least thermodynamically stable. |
| Nicotinamide (B3_B) | Fast initial change, stable final complex. | Highest affinity (most negative ΔGrs among pyridines). | The complex is both kinetically accessible and thermodynamically favoured, likely due to optimal electronic fit and bond strength. |
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