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. 2025 Dec 18;26(24):12171. doi: 10.3390/ijms262412171
AE Adverse event
AI Aromatase inhibitor
AKT Ak strain transforming
ALT Alanine transaminase
AST Aspartate aminotransferase
BC Breast cancer
BP Blueprint
BRCA Breast cancer gene
CBR Clinical benefit rate
CDK4/6i Cyclin-dependent kinase 4/6 inhibitor
CPS Combined positive score
CT Chemotherapy
CTLA-4 Cytotoxic T-lymphocyte-associated protein 4
DCR Disease control rate
ddAC Dose-dense doxorubicin plus cyclophosphamide
DDR DNA damage response
DOR Duration of response
EBC Early breast cancer
EC Epirubicin plus cyclophosphamide
EFS Event-free survival
ER Estrogen receptor
ET Endocrine therapy
FOXP3 Forkhead box P3
HDAC Histone Deacetylase
HER2 Human epidermal growth factor receptor 2
ICI Immune checkpoint inhibitor
IDFS Invasive disease-free survival
ILD Interstitial lung disease
KN-756 KEYNOTE-756
LAG3 Lymphocyte activation gene 3
LumB Luminal B
MBC Metastatic breast cancer
mDOR Median duration of response
MHC Major histocompatibility complex
mo months
MP Mammaprint
mPFS Median progression free survival
mTNBC Metastatic triple-negative breast cancer
mut/MB Mutations per Megabase
NA Not applicable
NACT Neoadjuvant chemotherapy
NR Not reported
ORR Objective response rate
OS Overall survival
PAM50 Prediction analysis of microarray 50
PARPi Poly (ADP-ribose) polymerase inhibitor
pCR Pathological complete response
PD-1 Programmed cell death protein 1
PD-L1 Programmed cell death-ligand 1
PR Partial response
RCB Residual cancer burden
RT Radiation therapy
SBRT Stereotactic body radiation therapy
SD Stable disease
STING Stimulator of interferon genes
TAM Tumor-associated macrophages
TIL Tumor-infiltrating lymphocytes
TMB Tumor mutation burden
TME Tumor microenvironment
TNBC Triple-negative breast cancer
TRAE Treatment-related adverse events
Treg Regulatory T cells