Authors	Study Design	Population	Form of Exposure	Most Probable	Worst Case	Outcome Measured	Study Quality
D. H. Rochlin, C. M. Rajasingh, Y. L. Karanas et al. [28]	Case Report	23-year-old healthy woman who worked as a chemist in a laboratory	dermal exposure	-	-	Healing of the wound, electrolyte testing	JBI Checklist for Case Reports: Include
J. Y. Byun, J. Y. Woo, Y. W. Choi et al. [29]	Case Report	24-year-old Korean man, healthy, job at an organic chemistry laboratory	airborne dermal contact	-	-	allergic contact dermatitis: patch tests	JBI Checklist for Case Reports: Include
C. Sun, B. Corbett [30]	Case Report	27-year-old male with no past medical history	dermal exposure	-	-	distal sensation, strength, pulses, laboratory studies, telemetry monitoring, chemical burn evolution	JBI Checklist for Case Reports: Include
C. Nguyen, N. R. Rose, D. B. Njoku [31]	Case Report	4-year-old child tonsillectomy and adenoidectomy	halothane anesthesia	-	-	Acute liver failure and clinical course	JBI Checklist for Case Reports: Include
H. Wark, J. Earl, D. Chau et al. [14]	Case Series	infants of two and five months	halothane anesthesia	Patient 1: 29.3 mg/kg bw; Patient 2: 14.2 mg/kg bw	NA	TFA in the bile	(JBI) Critical Appraisal Checklist for Case Series- seek further information (questions about methods are open)
J. Dahlin, M. Engfeldt, C. Svedman et al. [32]	Case Series	One 22-year-old male, 4 women between 29 and 48 years of age; all worked at the same medium-sized company, which uses trifluoroacetic acid in its production process	dermal exposure	-	-	Healing of the Skin, blood levels, liver levels	(JBI) Critical Appraisal Checklist for Case Series: Include
P. Hoet, ML. M. Graf, M. Bourdi et al. [33]	Case Series	industrial workers	inhalation of Hydrochlorofluorocarbons	-	-	acute hepatitis/liver disorders: blood biochemistry, liver biopsy sample,	(JBI) Critical Appraisal Checklist for Case Series- seek further information (questions about methods open)
J. B. Bentley, R. W. Vaughan, A. J. Gandolfi et al. [18]	Observational Study	17 morbidly obese, 8 nonobese patients	halothane anesthesia	Obese: 9.1 mg/kg bw; Nonobese: 9.4 mg/kg bw (body weight)	Obese: 42.3 mg/kg bw; Nonobese: 43.6 mg/kg bw	TFA Level in blood	Newcastle–Ottawa Scale (NOS): 6 of 9
R. Takiyama, M. Morio, K. Fujii et al. [13]	Observational Study	Japanese patients without history of blood transfusion, liver disease, general anesthesia, or drug injection; 6 low halothane concentration, 6 high halothane concentration	halothane anesthesia	Group 1 (low dose, long duration): 43 ± 6 mg/kg bw; Group 2 (high dose, short duration): 40 ± 10 mg/kg bw	NA	TFA in urine	Newcastle–Ottawa Scale (NOS): 6 of 9
T. S. Sutton, D. D. Koblin, L. D. Gruenke et al. [20]	Observational Study	13 healthy volunteers, 26 healthy patients undergoing elective surgery	desflurane anesthesia	Volunteers: 2.6 mg/kg bw; Patients: 1.1 mg/kg bw	Volunteers: 12.2 mg/kg bw; Patients: 5.1 mg/kg bw	TFA in blood and urine	Not enough information for a NOS assessment
R. Wegner, B. Rincker, B. Poschadel et al. [26]	Observational Study	All operation staff (anesthetists, surgeons, nurses); 15 men, 16 women	inhalation of halothane	Anesthetists: 0.016 mg/kg bw; Surgeons: 0.008 mg/kg bw; Surgery staff: 0.007 mg/kg bw; Floaters: 0.004 mg/kg bw	Anesthetists: 0.064 mg/kg bw; Surgeons: 0.031 mg/kg bw; Surgery staff: 0.030 mg/kg bw; Floaters: 0.015 mg/kg bw	TFA in urine	Newcastle–Ottawa Scale (NOS): 6 of 9
R. A. Moore, K. W. McNicholas, J. D. Gallagher et al. [19]	Observational Study	Patients with congenital heart disease scheduled for open-heart surgery	halothane anesthesia	Acyanotic: 36 mg/kg bw; Cyanotic: 37 mg/kg bw	Acyanotic: 168 mg/kg bw; Cyanotic: 171 mg/kg bw	TFA in blood	Newcastle–Ottawa Scale (NOS): 5 of 9
E. Dallmeier, D. Henschler [34]	Pharmacokinetic study	Volunteers	inhalation of halothane	-	-	TFA in blood	Expert opinion: trustworthy
H. Schaffernicht, D. Kuchenbecker, J. Lehmann [25]	Pharmacokinetic study	5 anesthetists, 8 volunteers	inhalation of halothane	Anesthetists: 0.84 mg/kg bw; Volunteers 0.90 mg/kg bw	Anesthetists: 6.3 mg/kg bw; Volunteers 7.2 mg/kg bw	TFA in urine	Expert opinion: trustworthy
H. Wark, J. Earl, D. D. Chau et al. [15]	Pharmacokinetic study	Children with mean age of 74 months; 5 healthy, one with cystic fibrosis	halothane anesthesia	15.9 ± 3.6 mg/kg bw	NA	TFA in urine	Expert opinion: trustworthy
S. Y. Monté, I. Ismail, D. N. Mallett et al. [17]	Pharmacokinetic study	healthy male volunteers	inhalation of HFA-134a	Volunteer 1: 0 µg/kg bw; Volunteer 2: 0.023 µg/kg bw; Volunteer 3: 0.027 µg/kg bw; Volunteer 4: 0.068 µg/kg bw	Volunteer 1: 0.075 µg/kg bw; Volunteer 2: 0.041 µg/kg bw; Volunteer 3: 0.048 µg/kg bw; Volunteer 4: 0.102 µg/kg bw	TFA in urine	Expert opinion: trustworthy
H. Wark, J. Earl, D. D. Chau et al. [16]	Pharmacokinetic study	children; 5 healthy; one with cystic fibrosis, chronic lung disease and proven liver disease	halothane anesthesia	15.9 ± 3.6 mg/kg bw (comparison halothane metabolism in children)	NA	TFA in urine	Expert opinion: trustworthy