FIG. 1.

Cumulative mortality of rabbits infected intracisternally with C. immitis and given one of the indicated treatments. A χ² test for homogeneity was done on the survival in the D5W treatment arms (Table 1), in which the total number of animals surviving in blocks 1, 2, and 3 were compared (e.g., two of eight, two of eight, and five of eight animals, respectively) and showed that P was equal to 0.2019 (χ² = 3.2; two degrees of freedom). Thus, the survival results for the D5W treatments were pooled across the blocks. The statistical analyses of survival times by a log rank test showed that treatment with FLC (FCZ), AMB, and all doses of AmBi significantly prolonged survival compared with that with D5W treatment (P = 0.0001).